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When AGGRENOX capsules have been taken having a substantial Excess fat meal, there was no distinction for aspirin in AUC at continual-condition, as well as the close to fifty% reduce in Cmax wasn't thought of clinically suitable depending on the same diploma of cyclooxygenase inhibition evaluating the fed and fasted condition.
The approximated history hazard of important birth defects and miscarriage with the indicated population is unknown. All pregnancies Possess a track record possibility of delivery defect, loss, or other adverse results.
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Within a analyze carried out with an intravenous formulation of dipyridamole, sufferers with moderate to intense hepatic insufficiency showed no improve in plasma concentrations of dipyridamole but showed a rise in the pharmacologically inactive monoglucuronide metabolite. Dipyridamole might be dosed without having restriction given that there isn't a proof of hepatic failure.
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Chest Discomfort. Aspirin/dipyridamole could potentially cause upper body pain, that may be a symptom of a coronary heart assault. The potential risk of upper body pain is enhanced in those with current cardiovascular disease.
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